The safety of 3-methyl-5-cyclopentadecen-1-one has been evaluated by the Research Institute for Fragrance Materials (RIFM), with a peer-reviewed safety assessment published. It was found to have the potential for skin sensitization in a small percentage of individuals. This means that in a limited number of people, repeated contact may cause a temporary reaction, including skin redness, rash or itching.
To prevent sensitization, RIFM has established a maximum acceptable concentration for this ingredient, and the International Fragrance Association (IFRA) has issued a safe use standard for 3-methyl-5-cyclopentadecen-1-one in household and personal care products. Most individuals will not be affected, but if you have questions, consult a healthcare professional.