The safety of p-tert-Butylcyclohexanone has been evaluated by the Research Institute for Fragrance Materials (RIFM), and a peer-reviewed safety assessment has been published. It was found to have the potential to cause skin sensitization in a small percentage of individuals. This means that in a limited number of people, repeated contact may cause a temporary reaction, including skin redness, rash or itching.
To prevent sensitization, RIFM has established a maximum acceptable concentration level for this ingredient, and the International Fragrance Association (IFRA) has set safe usage standards for p-tert-Butylcyclohexanone in household and personal care products. Although an ingredient may have the potential for skin sensitization, most people will not be affected. Everyone's skin is different, so consult a healthcare professional with any questions you may have.